Alzheimer’s and Parkinson’s are brain diseases in which the gradual degeneration of neurons leads to loss of speech, memory, and thinking.
Existing remedies are intended only to suppress symptoms, but they cannot stop the neurodegeneration process itself.
Now, Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer’s, Parkinson’s, and other serious brain pathologies.
New molecules of the pyrrolyl and indolylazine classes activate intracellular mechanisms to combat one of the main causes of “aging” brain diseases: an excess of so-called amyloid structures that accumulate in the human brain with age.
Experts from various institutes participated in the study, including the Ural Federal University, published in the European Journal of Medicinal Chemistry.
“Our compounds activate the synthesis of specific heat shock proteins and cause their accumulation in the cell,” said research co-author, professor at the Department of Organic and Biomolecular Chemistry at UrFU Irina Utepova.
“Proteins of this type make it possible to protect neuronal tissue from an excess of toxic amyloids and protect cells from various types of stress, including the proteotoxic stress characteristic of neurodegenerative diseases.”
The important advantages of the compounds of the pyrrolyl and indolylazine class series are a low-toxicity and cost-effective synthesis technology.
The obtained compounds were tested in cellular models of Alzheimer’s disease and secondary injuries after traumatic brain injury.
In both cases, the new substances demonstrated a significant therapeutic effect, increasing the survival of neuronal cells. The most effective compound has been tested in living tissues of rats with secondary injuries after traumatic brain injury.
According to the scientists, the use of pyrrolylazine in rehabilitation therapy allowed the animals to avoid the occurrence of movement disorders and the degeneration of neurons in the hippocampus.
The research team, consisting of experts from the Institute of Cytology of the Russian Academy of Sciences, the Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences and the Ural Federal University, participated in the study. . to study the mechanism of action of new compounds and is preparing for their preclinical testing.
We will keep you updated on what will happen next with this hopeful investigation.
Fountain: Ural Federal University
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